In vitro Nanotoxicity
We represent a benchmark in the new in vitro nanotoxicology discipline, an area where we have a great deal of experience in developing and validating toxicological studies of nanomaterials.
Our lines of technological activity:
Studies with nanomaterials (virgin and coated)
- Studies to establish the viability of cell lines and primary cultures derived from different organs (hepatocytes, keratinocytes, fibroblasts, etc.)
- Genotoxicity studies (AMES test, COMET test, micronucleus test)
- Haemolysis
- Inflammation evaluation (ex vivo and cellular models)
- Cellular stress evaluation (ex vivo and cellular models)
- Penetration through physiological barriers according to exposure pathway (respiratory tract epithelium, intestinal, the skin, the brain)
- Study of molecular response by conventional PCR, high-performance genomic and proteomic analyses to identify biomarkers that can be used as new target points
- Percutaneous absorption (OECD directive 428)
- Dermal irritation (OECDTG 404)
- Cutaneous corrosion (OECD 431, 435)
- Ocular irritation (Invittox no. 37)
- In vitro toxicity by inhalation (encompassing experiments of acute, sub-chronic and chronic exposure)
- Customised studies on demand according to nanomaterial specifications
- Experience from the perspective of existing regulations with a view to contributing to the development of drugs and
dermocosmetics based on nanosystems