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in vitro and ex vivo physiological models

 Modelos fisiológicos in vitro y ex vivo

We work on and develop in vitro models of the major physiological barriers. This means that we are able to reproduce fast and reliable predictive systems at lab-scale for studying the behaviour of drugs, dermocosmetics, food ingredients, nanoparticles and of any product likely to have an effect on human health.

Our lines of technological activity are:

  • Skin
    • o Human skin explants: human epithelial tissue cultures composed of epidermis or dermis and epidermis, with numerous variations of thickness/size, and the separation and obtaining of a single layer of tissue, etc. in order to adapt to the type of experiment to be carried out.

      • - Tests to ensure safety and effectiveness of the active substance or formula on healthy skin
      • - Tests to ensure safety and effectiveness of the active substance or formula on damaged skin
      • - Phototoxicity studies. (OECD 432). Permeability (Percutaneous absorption OECD 428).

    • 3D model (RHE: Reconstituted human epidermis model).

      • - Dermal irritation (OECD 404)

  • Artificial biobarrier

    • -In vitro corrosivity (OECD 435/Invittox no. 116).

  • Ocular
    Human corneal epithelial model (HCE Model)

    • - Ocular irritation (pre-validated by ECVAM in a multicentric study)
    • - Ocular effectiveness and cleaning studies.

  • Oral
    Human oral epithelial model (HOE Model)

    • - Oral irritation (ECVAM validation underway)
    • - Oral cleaning and effectiveness studies

  • Pulmonary and nasal
    3D pulmonary epithelium (Mucilair™)

    • - Exposure to inhaled products (solid, liquid, nanomaterials, etc.)
    • - Evaluation of the formulas of active substances
    • - Evaluation of the safety and effectiveness of drugs and active substances for EPOC, asthma, cystic fibrosis, etc.
    • - Multiple-dose studies and the study of sub-acute and chronic toxicity (up to 6-9 months)

  • Blood-brain barrier
    In vitro blood-brain barrier model (BHE): barrier models based on the co-cultures of endothelial and glial cells. Models developed through immortalised endothelial lines, and models of primary cultures of microvascular cells from a bovine brain.

    • - Studies of BBB permeability and effectiveness for an active substance or drug.
    • - Study of the transport mechanisms involved in the passing of an active substance through the BBB.
      • Neurotoxic profiles of an active substance

  • Intestinal
    Caco2 cell model: differentiated in a polarised monolayer. Bidirectional transport: apical-basolateral/basolateral-apical:

    • Evaluation of low/high permeability
    • Evaluation of active/passive transport
    • Study of studio interactions at transporter level:
      • Pgp
      • BCRP
    • - Drug interaction studies (FDA).
    • - Evaluation of carriers

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Parque Tecnológico, Ed. 202. 48170 Zamudio (Bizkaia) SPAIN

T.: +34 94 6002323, F.: +34 94 6002324

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